An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

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An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro.

Despite the success of highly active antiretroviral therapy (HAART) in lowering circulating HIV-1 to undetectable levels in most infected individuals, several studies have documented the presence of a small reservoir of latently infected cells in HAART patients, the majority of which are CD45RO(+) memory T cells. We previously have demonstrated that latently infected, replication-competent cell...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1999

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.96.20.11482